Hydroxypropyl Methylcellulose (HPMC) bụ polymer vasatail eji eme ihe n'ọtụtụ ụlọ ọrụ dị iche iche, gụnyere ọgwụ, nri, ihe ịchọ mma na ihe owuwu.Ngwongwo ya pụrụ iche na-eme ka ọ bụrụ ezigbo onye nyocha maka ngwa dị ka ntọhapụ ọgwụ a na-achịkwa, ihe ndị na-emepụta ihe, mkpuchi ihe nkiri, na ihe owuwu.N'isiokwu a, anyị ga-abanye n'ime usoro mgbasa nke HPMC, na-enyocha mkpa ya, usoro na ngwa ya.Ịghọta usoro mgbasa nke HPMC dị oke mkpa maka ịkwalite arụmọrụ ya yana nweta nsonaazụ achọrọ na mpaghara dị iche iche.
Mkpa mgbasa nke HPMC
Mgbasa nke HPMC na-ezo aka na usoro nke ịgbasa na igbari polima na ọkara mmiri mmiri.Nzọụkwụ a dị oke mkpa ka ọ na-ekpebi ọnụego ntọhapụ, bioavailability, na arụmọrụ nke ngwaahịa dabere na HPMC.Omume mgbasa nke HPMC dabere na ihe dị iche iche, gụnyere ọkwa nke HPMC, nha urughuru, okpomọkụ, pH, na ọdịdị nke ọkara.Site n'ịmụ usoro mgbasa, ndị na-eme nchọpụta na ndị na-emepụta ihe nwere ike nyochaa solubility, ntọhapụ kinetics, na n'ozuzu arụmọrụ nke HPMC formulations, na-eduga na enwekwukwa ngwaahịa mmepe na njikarịcha.
Usoro maka mgbasa HPMC
A na-eji ọtụtụ usoro iji mụọ omume mgbasa nke HPMC.Ụzọ ndị a na-ejikarị eme ihe gụnyere:
a.Ngwa nke mbụ (ngwa nkata): Usoro a gụnyere ịtinye ihe nlele HPMC n'ime nkata ntupu, nke a na-emikpu n'ime ihe mgbaze mgbe a na-akpali ya.A na-ejikarị usoro a maka usoro mwepụta ozugbo ma na-enye ozi bara uru na ọnụego mgbasa na profaịlụ ntọhapụ nke HPMC.
b.Ngwa II ( Ngwa Paddle): Na usoro a, a na-etinye ihe nlele ahụ n'ime arịa mgbasa, a na-eji paddle mee ka ọ kpalie.Usoro a dabara adaba maka ntọhapụ ozugbo yana usoro mwepụta agbatị, na-enye nghọta n'ime ọnụego mgbasa na ntọhapụ kinetics nke HPMC.
c.Ngwa III ( Ngwa cylinder na-emegharị ihe): Usoro a gụnyere ịtinye ihe nlele ahụ na cylinder na-emegharịghachi, nke na-aga azụ na azụ na usoro mgbasa.A na-ejikarị usoro a maka ịmụ usoro mwepụta gbatịa dabere na HPMC ma na-enye ozi gbasara ọnụego ntọhapụ na omume mgbasa ọgwụ.
d.Ngwa IV (ngwa-site na cell ngwa): A na-eji usoro a eme ihe maka ịmụ ihe mgbochi transdermal dabere na HPMC.A na-etinye ihe nlele ahụ n'etiti akụkụ abụọ, a na-ahapụkwa usoro mgbasa ozi ka ọ na-agafe na nlele ahụ, na-eme ka mwepụta ọgwụ ahụ gafee akpụkpọ ahụ.
Ngwa nke usoro mgbasa HPMC
Usoro mgbasa nke HPMC na-achọta ngwa dị ukwuu na ụlọ ọrụ dị iche iche:
a.Ụlọ ọrụ na-emepụta ọgwụ: A na-eji HPMC eme ihe dị ka polymer matrix maka nhazi mwepụta ọgwụ a na-achịkwa.Usoro mgbasa ozi na-enyere aka ikpebi ọnụego ntọhapụ, omume mgbasa ozi ọgwụ, na usoro ntọhapụ nke mbadamba, capsules na pellet dabere na HPMC.Ozi a dị oke mkpa maka ịkwalite nnyefe ọgwụ yana hụ na nsonaazụ ọgwụgwọ na-agbanwe agbanwe na nke a na-ahụ anya.
b.Ụlọ ọrụ nri: A na-eji HPMC dị ka ihe na-eme ka ọ sie ike ma na-eme ka ahụ sie ike na ngwaahịa nri dị ka sauces, uwe, na ihe ọṅụṅụ.Usoro mgbasa ozi na-enyere aka n'ịghọta njirimara hydration na solubility nke HPMC na matrices nri dị iche iche, na-enye aka n'ịhazi udidi, nkwụsi ike, na njirimara mmetụta nke ngwaahịa ikpeazụ.
c.Ụlọ ọrụ ịchọ mma: HPMC na-arụ ọrụ na ịchọ mma na ngwaahịa nlekọta onwe onye dị ka onye na-emepụta ihe nkiri, emulsion stabilizer, na viscosity modifier.Usoro mgbasa ozi na-enyere aka nyochaa njiri ike na ihe na-emepụta ihe nkiri nke HPMC, na-eme ka udidi ngwaahịa achọrọ, mgbasawanye, na nkwụsi ike ndụ.
